Thomas O. Crawford, MD
A-T Clinical Center at Johns Hopkins Hospital
This placebo controlled cross-over trial was performed to determine if treatment with the drug Baclofen improves balance and tremor as well as certain eye movement abnormalities associated with A-T.
At the dose used – 10 mg tablets with dose escalation up to a maximum dose of 30 mg / day – Baclofen did not have a significant effect on tremor, eye movement or balance deficits in the study participants. Higher doses of baclofen, or alternative drugs, may be useful and are worth trying. The tests used to measure eye movements, balance and tremor were proven accurate and suitable for use in future trials.